Fingerprinting Diet-Driven Changes in the Gut Volatilome
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By
February 4, 2026
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2 min
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1
Study examines changes in human fecal volatilome.
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Dietary intervention included gluten-free diet and probiotics.
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3
Utilized GC×GC-TOFMS for analysis.
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4
Identified approximately 270 VOCs.
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Coordinated shifts in VOCs linked to gut microbiota were observed.
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6
Method allows for broad detection of metabolic variations.
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7
Study expands catalog of human fecal volatiles by 20%.
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8
Offers insights into personalized nutrition and biomarker discovery.
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A study reveals that dietary intervention and probiotic supplementation lead to significant changes in the human fecal volatilome. Researchers analyzed fecal samples from individuals with non-celiac gluten/wheat sensitivity undergoing a dietary protocol, revealing coordinated shifts in volatile organic compound profiles related to gut microbial activity. By employing comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry, the study identified approximately 270 annotated VOCs, enhancing understanding of the metabolic response to dietary changes and providing a platform for further biomarker discovery in personalized nutrition.
-
1
Study examines changes in human fecal volatilome.
-
2
Dietary intervention included gluten-free diet and probiotics.
-
3
Utilized GC×GC-TOFMS for analysis.
-
4
Identified approximately 270 VOCs.
-
5
Coordinated shifts in VOCs linked to gut microbiota were observed.
-
6
Method allows for broad detection of metabolic variations.
-
7
Study expands catalog of human fecal volatiles by 20%.
-
8
Offers insights into personalized nutrition and biomarker discovery.
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