What I Learned Bringing Slalom Chromatography Back from the Dead
November 18, 2025
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9 min
7 Key Takeaways
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1
Slalom chromatography revived for separating large biomolecules.
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2
Insights from physics essential for understanding DNA behavior.
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3
Key focus on shear forces affecting DNA migration.
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4
Importance of interdisciplinary collaboration highlighted.
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5
New educational approaches needed for scientists.
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6
Emphasis on broad scientific education for innovation.
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7
Waters commercialized the first SC column, marking significant advancement.
The development of slalom chromatography (SC) represents a forward leap in separating large biomolecules crucial for cell and gene therapies. Originally conceptualized in the late 1980s, its rigorous revival was urged by the shortcomings of traditional chromatographic methods. Researchers, led by insights into the behavior of DNA under shear forces, have created a foundational understanding of SC, paving the way for commercial implementation. This interdisciplinary endeavor emphasizes the necessity of broad scientific education to cultivate innovative solutions in biopharmaceutical development.
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