Faster Sodium Correction Gains Support
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By
January 27, 2026
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3 min
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1
Faster sodium correction in severe hyponatremia reduces 90-day mortality risk.
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Study analyzed 13,988 patients with severe hyponatremia from 2008-
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21% of patients experienced primary outcomes.
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4
Fast correction (>12 mEq/L/24 hours) was associated with lower risks.
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5
Concerns remain about osmotic demyelination syndrome.
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Study concludes treatment guidelines may need reevaluation.
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A retrospective cohort study led by Dr. Dustin G. Mark from Kaiser Permanente revealed that faster correction of severe hyponatremia reduces the risk of 90-day death and delayed neurologic events. Analyzing 13,988 hospitalized patients, the study showed significant associations between medium and fast correction rates and decreased primary outcomes. Despite concerns about osmotic demyelination syndrome with rapid corrections, the findings suggest a reevaluation of treatment guidelines is necessary. The study analyzed patients with multiple comorbidities over 15 years.
-
1
Faster sodium correction in severe hyponatremia reduces 90-day mortality risk.
-
2
Study analyzed 13,988 patients with severe hyponatremia from 2008-
-
3
21% of patients experienced primary outcomes.
-
4
Fast correction (>12 mEq/L/24 hours) was associated with lower risks.
-
5
Concerns remain about osmotic demyelination syndrome.
-
6
Study concludes treatment guidelines may need reevaluation.
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