From the Journals

Blood Tau Trajectories Tied to Alzheimer Onset

Repeated blood tau measurements were associated with age at symptom onset among individuals at risk for Alzheimer disease 

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    p-tau217 biomarker linked to Alzheimer's onset.

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    Longitudinal measurements aid in understanding disease progression.

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    Individualized 'biomarker clock' models estimate age at positivity.

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    Data sourced from two major research cohorts.

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    Older individuals may progress to symptoms more rapidly.

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    Models can enhance clinical trial design but not for individual prognostication.

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    Variability in model performance noted with different assays.

Original Source(s)

Blood Tau Trajectories Tied to Alzheimer Onset

Repeated blood tau measurements were associated with age at symptom onset among individuals at risk for Alzheimer disease 

  • by Henry Thomas

  • February 26, 2026

  • 3 min

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