Accounting for Eye Correlation Improves Statistical Accuracy
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By
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March 23, 2026
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3 min
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1
- The study focuses on statistical models in ophthalmic research. - Treating both eyes as independent leads to inflated false-positive rates. - Mixed effects models are preferred for eye-level predictors. - Averaging is suitable for subject-level predictors. - Statistical power was assessed across various sample sizes. - Generalized estimating equations showed elevated error rates in smaller samples. - Importance of model selection in avoiding misleading results. - No conflicts of interest reported by researchers.