From the Journals

Proteomic Profiling Defines Vascular Cell States

Label-free LC–MS profiles nearly 5,000 cells, resolving smooth muscle subtypes and disease-associated phenotypes 

  • March 18, 2026

  • 2 min

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    Novel label-free workflow enables single-cell proteomics.

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    Study focused on vascular tissue related to Marfan syndrome.

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    Average of 500 proteins quantified per single cell.

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    Major cell types identified include smooth muscle and endothelial cells.

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    Increased LRP1 and PRSS2 associated with disease phenotypes.

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    Multi-omic approaches deepen understanding of cellular states.

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    Findings linked to changes in aneurysm progression.

Original Source(s)

Proteomic Profiling Defines Vascular Cell States

  • March 18, 2026

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