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A Simpler, Smarter CHO Strategy for High-Quality Bispecifics

Here’s how next-generation cell line and manufacturing methods can boost productivity, improve purity, and remove bottlenecks in bispecific antibody development

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  • 1

    Bispecific antibodies can bind multiple antigens.

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    CHO cell lines facilitate complex antibody production.

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    Glutamine synthetase is essential for selection.

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    The J.MD platform integrates AI for molecule design.

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    Split GS method enhances antibody expression without antibiotics.

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    Continuous manufacturing improves efficiency.

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    Empirical optimization of plasmid ratios boosts yields.

Original Source(s)

A Simpler, Smarter CHO Strategy for High-Quality Bispecifics

Here’s how next-generation cell line and manufacturing methods can boost productivity, improve purity, and remove bottlenecks in bispecific antibody development

  • by Yiting Lim

  • February 19, 2026

  • 10 min

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