7 Key Takeaways
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1
Oligonucleotides are crucial in therapeutic research post-pandemic.
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2
Precise analysis is essential but challenging.
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3
Traditional columns fail for oligonucleotide analysis.
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4
IP-RP chromatography is the preferred method.
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5
The Sepapure oliGO column offers high precision and durability.
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6
Affordability is a focus to boost research.
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7
Successful method transfer from existing products with low back pressure improvements.
Oligonucleotides have surged in importance since the COVID-19 pandemic, with applications spanning personalized medicine and mRNA technology. Their analysis presents challenges, given the need for precise differentiation of nearly identical sequences. Traditional reversed-phase columns are ineffective due to the polar nature of oligonucleotides; however, ion-pair reversed-phase (IP-RP) chromatography has emerged as the preferred analytical method. The new Sepapure oliGO column offers high precision, robustness, and affordability, facilitating advances in oligonucleotide research.
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