From the Journals

Tumor Budding May Predict Survival in Head and Neck Cancer

Tumor budding emerges as a practical histologic marker, as clinicians seek low-cost predictors of occult metastasis in surgically treated patients.

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    High tumor budding correlates with poor prognosis in head and neck squamous cell carcinoma.

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    26% survival rate for high tumor budding vs. 85% for low.

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    Optimal cutoff for buds is 4.

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    Independently predicts overall survival and lymph node metastasis.

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    Requires validation in larger studies.

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    Associated with aggressive cancer features.

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    Practical marker for guiding treatment decisions.

Original Source(s)

Tumor Budding May Predict Survival in Head and Neck Cancer

Tumor budding emerges as a practical histologic marker, as clinicians seek low-cost predictors of occult metastasis in surgically treated patients.

  • by Stanley Gajete

  • August 14, 2025

  • 3 min

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