From the Journals

Anti-CD146 Linked to Silica in Systemic Sclerosis

Comparative analysis across exposed workers, cancer controls, and healthy donors supports specificity.

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  • 1

    Anti-CD146 autoantibodies may indicate occupational exposure in systemic sclerosis.

  • 2

    15% of systemic sclerosis patients tested positive compared to 5% of healthy controls.

  • 3

    Primary exposure linked to crystalline silica.

  • 4

    Antibody sensitivity: 57%, specificity: 88%.

  • 5

    Findings suggest AACD146 as a promising biomarker in systemic sclerosis management.

Original Source(s)

Anti-CD146 Linked to Silica in Systemic Sclerosis

Comparative analysis across exposed workers, cancer controls, and healthy donors supports specificity.

  • by Kathryn Wighton

  • March 5, 2026

  • 3 min

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