From the Journals

CKD Markers Linked to Cognitive Risk

In adults with chronic kidney disease, higher proteinuria and lower estimated glomerular filtration rate are associated with increased risk of incident cognitive impairment.

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  • 1

    Study reports 38% increased risk of cognitive impairment with CKD and high UPCR.

  • 2

    Analyzed 5,607 adults with chronic kidney disease.

  • 3

    Each standard deviation increase in UPCR linked to 21% likelihood of cognitive issues.

  • 4

    eGFR decreases correlate with cognitive decline but affected by UPCR.

  • 5

    Joint modeling shows effects of filtration and UPCR on cognitive health.

  • 6

    Conducted within CRIC Study with longitudinal assessments.

  • 7

    Limitations include potential misclassification and loss to follow-up.

Original Source(s)

CKD Markers Linked to Cognitive Risk

In adults with chronic kidney disease, higher proteinuria and lower estimated glomerular filtration rate are associated with increased risk of incident cognitive impairment.

  • by Kathryn Wighton

  • February 17, 2026

  • 3 min

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