Leptin's Role in Energy Deficiency Syndromes

7 Key Takeaways

• 1

  Relative Energy Deficiency in Sport (REDs) is a condition affecting athletes and military personnel.

• 2

  REDs involves multiple physiological systems and is not limited to the Female Athlete Triad.

• 3

  Energy availability is a key factor, with levels below 30 kcal/kg fat-free mass per day triggering substantial disruptions.

• 4

  Leptin, a hormone produced by fat tissue, is identified as a potential key regulator in REDs.

• 5

  Current recommendations focus on nutritional and behavioral modifications for prevention and treatment.

• 6

  The International Olympic Committee has incorporated these findings into its consensus statement on REDs.

• 7

  The authors declared no competing interests.