From the Journals

Autism Trajectories: What the Data Suggest

Two genetic factors may shape autism’s age of diagnosis and mental health overlap. 

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  • 1

    Study in Nature explores autism's polygenic architecture.

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    Two correlated genetic factors associated with age at diagnosis identified.

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    Early-childhood-emergent and late-childhood-emergent trajectories found.

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    Common variants explain ~11% of age at diagnosis variance.

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    Genetic correlations observed with various psychiatric traits.

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    Limitations include focus on European ancestry and reliance on non-autism-specific SDQ.

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    Results may inform diagnostic timing and intervention strategies.

Original Source(s)

Autism Trajectories: What the Data Suggest

Two genetic factors may shape autism’s age of diagnosis and mental health overlap. 

  • by Kerri Miller

  • October 3, 2025

  • 3 min

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