Tau Biomarker Expands Beyond Alzheimer’s

Study finds elevated phosphorylated tau in AL and ATTR amyloidosis, suggesting a potential blood biomarker for amyloid-related neuropathy

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Elevated phosphorylated tau levels noted in AL and ATTR amyloidosis patients.
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Study involved 280 individuals across multiple European countries.
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p-tau181 shows moderate diagnostic discrimination for systemic amyloidosis.
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Neuropathy associated with elevated p-tau181 levels in amyloidosis patients.
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Further studies needed to incorporate biomarkers in routine diagnostic workflows.
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p-tau217 also shows similar elevation pattern in amyloidosis patients.
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Elevated tau may reflect cellular responses to amyloid deposition.