From the Journals

Tranexamic Acid in General Surgery: POISE-3 Findings

“Tranexamic acid significantly reduced the risk of perioperative bleeding without increasing cardiovascular risk in patients undergoing general surgery procedures,” said Lily J. Park, MD, MSc, and colleagues.

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5 Key Takeaways

  • 1

    Tranexamic acid (TXA) significantly reduces perioperative bleeding in general surgery patients.

  • 2

    The study found a 26% reduction in relative risk of major bleeding with TXA.

  • 3

    TXA was associated with a reduced need for transfusion of packed red blood cells.

  • 4

    Subgroup analyses revealed significant reductions in bleeding risk for specific surgical subcategories.

  • 5

    The study highlighted TXA's effectiveness and safety in general surgery.

Original Source(s)

Tranexamic Acid in General Surgery: POISE-3 Findings

“Tranexamic acid significantly reduced the risk of perioperative bleeding without increasing cardiovascular risk in patients undergoing general surgery procedures,” said Lily J. Park, MD, MSc, and colleagues.

  • by Kathryn Wighton

  • January 23, 2025

  • 3 min

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