From the Journals

Surgery Versus GLP-1: Long-Term Diabetes Outcomes

Metabolic surgery associated with lower mortality and retinopathy risk versus glucagon-like peptide-1 therapy in diabetes and obesity.

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    Metabolic surgery reduces death rates by one-third compared to GLP-1 RAs.

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    The study analyzed 3,932 adults from 2010-

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    Primary endpoint: all-cause mortality.

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    Surgery led to a 9% death rate vs. 12% with medication.

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    Weight loss was greater: 21% post-surgery vs. 7% with GLP-1 RAs.

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    Complication risk was 7% with surgery.

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    Hemoglobin A1c decreased by 0.9% from surgery vs. 0.2% from medication.

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    Findings indicate significant additional benefits of surgery.

Original Source(s)

Surgery Versus GLP-1: Long-Term Diabetes Outcomes

Metabolic surgery associated with lower mortality and retinopathy risk versus glucagon-like peptide-1 therapy in diabetes and obesity.

  • by Kathryn Wighton

  • September 24, 2025

  • 2 min

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