Clinical Guidelines

Hypofractionated Locoregional RT in Early Breast Cancer

As reported in The Lancet by Rivera et al, 5-year results of a French phase III trial (UNICANCER HypoG-01) showed noninferiority of hypofractionated locoregional radiotherapy (RT) vs standard 5-week R...

Share

  • 1

    Study compared hypofractionated RT (40 Gy, 3 weeks) vs standard RT (50 Gy, 5 weeks).

  • 2

    Noninferiority for lymphedema risk was established.

  • 3

    1,221 women participated post-tumor resection.

  • 4

    Median follow-up was 4.8 years.

  • 5

    Similar incidence of arm lymphedema in both groups.

  • 6

    Most common adverse events were pain (69%) and fatigue (65%).

  • 7

    The research was funded by the French National Cancer Institute.

Original Source(s)

Hypofractionated Locoregional RT in Early Breast Cancer

  • by Matthew Stenger

  • March 20, 2026

Related Content

Trauma CT and Unexpected Findings

Investigators evaluate classification of incidental findings on trauma whole-body CT.

Can AI Clarify Lung Screening?

Study assesses comprehension of large language model-generated lung screening summaries

Calcium Score Model Tested in Chest Pain

Investigators compare calcium score–based strategies with universal coronary computed tomography angiography in patients with stable chest pain.