MDSpire - Takeaway
Clinical Guidelines

POEMS Syndrome: Diagnostic Clues From Neuropathy to Bone Marrow Findings

POEMS syndrome is a poorly understood and complex paraneoplastic plasma cell disorder characterized by peripheral neuropathy and multisystem involvement, including organomegaly, endocrinopathy, monocl...

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  • 1

    POEMS syndrome involves peripheral neuropathy and multisystem effects.

  • 2

    Diagnosis hinges on recognizing clinical symptoms and applying diagnostic criteria.

  • 3

    Elevated vascular endothelial growth factor is a key indicator.

  • 4

    Neuropathy typically manifests symmetrically and is predominantly demyelinating.

  • 5

    Timely diagnosis is crucial to prevent complications and improve outcomes.

Original Source(s)

POEMS Syndrome: Diagnostic Clues From Neuropathy to Bone Marrow Findings

  • by Syed Ali Abutalib, Angela Dispenzieri

  • March 24, 2026

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