Short-Term Pain Reduction for CRPS
December 18, 2025
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3 min
8 Key Takeaways
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1
Review focused on bisphosphonates for complex regional pain syndrome (CRPS).
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2
Included 11 trials with 754 participants, mostly CRPS type I.
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3
Examined pain intensity and adverse events as primary outcomes.
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4
Findings show short-term pain reduction potential.
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5
Long-term effects on pain intensity remain uncertain.
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6
Concerns about increased adverse events.
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7
Urges future research on patient selection.
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8
Evidence quality varied from moderate to low certainty.
A systematic review and meta-analysis in the Annals of Internal Medicine examined the efficacy and safety of bisphosphonates for treating complex regional pain syndrome (CRPS), a chronic pain disorder usually affecting a limb after injury. The analysis included data from 11 trials with 754 adult participants, predominantly with CRPS type I. Findings showed bisphosphonates potentially reduce pain in the short term but have uncertain long-term effects. Concerns about increased adverse events were noted, highlighting a need for further research on patient selection.
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