From the Journals

Body Fat Distribution and Brain Health

A UK Biobank analysis links MRI-derived fat distribution patterns to differences in brain structure and neurologic outcomes.

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    Pancreatic-predominant and skinny-fat profiles linked to cognitive decline.

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    26,000 patients analyzed in UK Biobank study.

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    Six distinct fat distribution patterns identified.

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    Lower brain volume observed in non-lean profiles.

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    Increased risk of mood disorders across profiles.

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    Neuroanatomical alterations noted via imaging.

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    Profiles correlated with cognitive impairment in different sexes.

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    Findings suggest importance of fat distribution over BMI in neurologic risk assessment.

Original Source(s)

Body Fat Distribution and Brain Health

A UK Biobank analysis links MRI-derived fat distribution patterns to differences in brain structure and neurologic outcomes.

  • by Julie Greenbaum

  • February 2, 2026

  • 3 min

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