Anxiety Linked to Gut Disease Trajectories
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By
February 11, 2026
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3 min
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1
Anxiety is linked to a higher risk of developing IBS.
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2
IBS patients have an increased chance of developing anxiety.
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3
Study based on data from the TriNetX Global Collaborative Network.
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4
Follow-up period lasted up to 5 years.
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5
Causal inference is limited due to the retrospective design.
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6
Misclassification of diagnoses may affect results.
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7
Findings may not be generalizable due to exclusion criteria.
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8
Stronger association noted between anxiety and IBS than with IBD.
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Anxiety and irritable bowel syndrome (IBS) show a significant reciprocal relationship, with each condition linked to more than double the risk of developing the other, according to a study utilizing the TriNetX Global Collaborative Network's health records. The study analyzed adults aged 18 and older diagnosed with anxiety, IBS, or inflammatory bowel disease (IBD) between 2021 and 2024. Results indicate that patient histories reveal anxiety is associated with a higher subsequent diagnosis of IBS than vice versa. Despite its retrospective nature, the findings provide insights into these comorbid conditions. Limitations included potential misclassification and unmeasured confounding factors. Lead author Zachary Li emphasizes stronger associations between anxiety and IBS compared to IBD.
-
1
Anxiety is linked to a higher risk of developing IBS.
-
2
IBS patients have an increased chance of developing anxiety.
-
3
Study based on data from the TriNetX Global Collaborative Network.
-
4
Follow-up period lasted up to 5 years.
-
5
Causal inference is limited due to the retrospective design.
-
6
Misclassification of diagnoses may affect results.
-
7
Findings may not be generalizable due to exclusion criteria.
-
8
Stronger association noted between anxiety and IBS than with IBD.
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