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Sudden Death Trajectories in HFpEF, HFmrEF

Clinical changes before death overlap across outcomes

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  • 1

    Sudden death represents 25-30% of deaths in heart failure with preserved ejection fraction.

  • 2

    Study followed 6,001 patients with a median of 2.7 years.

  • 3

    Patients showed modest worsening of functional status before sudden death.

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    NYHA class and natriuretic peptide levels were key measures.

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    Current guidelines do not recommend ICDs for primary prevention.

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    Findings highlight non-specific pre-death changes, complicating risk assessment.

  • 7

    Study sponsored by Bayer AG, with disclosures from researchers reported.

Original Source(s)

Sudden Death Trajectories in HFpEF, HFmrEF

  • by Kathryn Wighton

  • March 31, 2026

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