Feature

Whole-Genome Sequencing Assay Detects HPV

HPV-DeepSeek identifies circulating HPV DNA, PIK3CA mutations, and integration events in pretreatment blood samples with high sensitivity and specificity.

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9 Key Takeaways

  • 1

    HPV-DeepSeek assay shows 9

  • 2

    7% sensitivity, 9

  • 3

    1% specificity.

  • 4

    Targets 43 HPV genotypes, crucial for early cancer detection.

  • 5

    Study involved 224 patients with HPV-associated squamous cell carcinoma.

  • 6

    High median genome coverage near 100% in true-positive cases.

  • 7

    Reports PIK3CA mutations and viral integration patterns.

  • 8

    Observations align with established cancer-site-specific tendencies.

  • 9

    Potential applications in treatment monitoring and assessing residual disease.

Original Source(s)

Whole-Genome Sequencing Assay Detects HPV

HPV-DeepSeek identifies circulating HPV DNA, PIK3CA mutations, and integration events in pretreatment blood samples with high sensitivity and specificity.

  • by Jim Gallagher

  • November 28, 2025

  • 4 min

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