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A Closer Look at Vascular Cell States in Marfan Syndrome

Single-cell proteomics identifies Marfan-enriched smooth muscle states and endothelial transition signatures

  • March 25, 2026

  • 2 min

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  • 1

    Single-cell proteomics reveals vascular cell states in Marfan syndrome.

  • 2

    Nearly 5,000 cells analyzed from aortic roots of mouse models.

  • 3

    Key cell types include endothelial cells and smooth muscle cells.

  • 4

    Identified 16 cell groups with distinct smooth muscle subtypes.

  • 5

    Disease-enriched populations associated with LRP1 and PRSS

  • 6

    Proteomics provides insights alongside RNA data.

  • 7

    New smooth muscle populations may impact aneurysm progression understanding.

Original Source(s)

A Closer Look at Vascular Cell States in Marfan Syndrome

  • March 25, 2026

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