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1
Study by Boston Children’s Hospital on tau protein.
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2
Focuses on distinct chemical signatures in tauopathies.
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3
Used FLEXITau for mass-spectrometry analysis.
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4
Mapped 145 post-translational modifications.
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5
Machine learning ranked modifications for disease classification.
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6
Absolute quantification is crucial for diagnostics and drug design.
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7
Each tauopathy has unique modification patterns.
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Recent research conducted by a team from Boston Children’s Hospital and affiliated institutions has highlighted distinct chemical signatures of pathological tau protein across various neurodegenerative diseases. Utilizing a novel technique called FLEXITau, researchers analyzed post-mortem brain tissue from 203 individuals affected by six different tauopathies, including Alzheimer's disease and chronic traumatic encephalopathy. This study emphasizes that each tauopathy has a unique combination of post-translational modifications and cleavage patterns, providing crucial insights for diagnostic and therapeutic applications.
-
1
Study by Boston Children’s Hospital on tau protein.
-
2
Focuses on distinct chemical signatures in tauopathies.
-
3
Used FLEXITau for mass-spectrometry analysis.
-
4
Mapped 145 post-translational modifications.
-
5
Machine learning ranked modifications for disease classification.
-
6
Absolute quantification is crucial for diagnostics and drug design.
-
7
Each tauopathy has unique modification patterns.
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