From the Journals

Sex-Stratified Genome Analysis Maps Depression Variants

X-chromosome variant and higher heritability distinguish male and female depression genetics.

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8 Key Takeaways

  • 1

    Identified sex-specific genetic differences in MDD.

  • 2

    16 variants in females, 8 in males.

  • 3

    Male variant rs5971319 linked to IL1RAPL

  • 4

    Higher MDD heritability in females.

  • 5

    Shared genetic regions included NEGR

  • 6

    Broader polygenicity found in women.

  • 7

    Study limitations include unequal sample sizes.

  • 8

    Sex-specific insights may inform precision medicine.

Original Source(s)

Sex-Stratified Genome Analysis Maps Depression Variants

X-chromosome variant and higher heritability distinguish male and female depression genetics.

  • by Stanley Gajete

  • October 23, 2025

  • 3 min

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