From the Journals

Can Testosterone Affect Cognitive Function? 

Systematic review finds modest, population-dependent effects on mood and cognition in adult men 

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  • 1

    Testosterone therapy may benefit mood and cognitive function modestly.

  • 2

    Study involved 11 trials with over 600 men aged 18 to

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    Clear benefits were noted in treatment-resistant depression.

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    Cognitive effects were domain-specific, not global.

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    Quality of life generally improved.

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    Common mild side effects included acne and injection-site reactions.

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    Recommended as a complementary treatment under endocrinologic supervision.

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    Further long-term trials are necessary.

Original Source(s)

Can Testosterone Affect Cognitive Function? 

Systematic review finds modest, population-dependent effects on mood and cognition in adult men 

  • by Henry Thomas

  • February 27, 2026

  • 3 min

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