Antibody Oxidation’s Hidden Handedness Comes Into View - Takeaway - MDSpire
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Antibody Oxidation’s Hidden Handedness Comes Into View

Integrated NMR and LC-MS analysis distinguishes elusive stereochemical forms of methionine oxidation in IgG1 Fc regions, offering a sharper tool for biologic drug quality control

  • April 8, 2026

  • 2 min

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  • 1

    New method reveals subtle methionine oxidation impacts in antibodies.

  • 2

    Focus on Met252 and Met428 in IgG

  • 3

    Combined NMR and LC-MS techniques used.

  • 4

    Important for stability and receptor interactions.

  • 5

    Potential improvements for therapeutic antibody manufacturing.

Original Source(s)

Antibody Oxidation’s Hidden Handedness Comes Into View

  • April 8, 2026

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