Not All Vitamin C Serums Penetrate the Same - Takeaway - MDSpire
Commentary & Perspectives

Not All Vitamin C Serums Penetrate the Same

Skin penetration data reveals a wide gap between popular formulations

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  • 1

    THD ascorbate penetrates 38 times more than AA and SA.

  • 2

    Study uses synthetic membrane for absorption measurement.

  • 3

    Higher early penetration of AA may indicate instability.

  • 4

    Lipophilic derivatives can cross skin barriers effectively.

  • 5

    Formulation stability impacts vitamin C's effectiveness.

  • 6

    Clinical efficacy remains untested in this research.

  • 7

    Key takeaway: the form of vitamin C and formulation affect absorption.

  • 8

    More questions arise about the real-world applicability of findings.

Original Source(s)

Not All Vitamin C Serums Penetrate the Same

  • by Kerri Miller

  • April 16, 2026

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