Small Shingles Risk Seen Post mRNA COVID-19 Booster
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by Doug Brunk
December 22, 2025
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4 min
7 Key Takeaways
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1
The study analyzed primary care records from over 2 million vaccinated individuals.
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2
A modest increase in shingles risk was found after the mRNA COVID-19 booster.
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3
No elevated risk was noted after the primary vaccination series.
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4
The adjusted IRR for herpes zoster after the booster dose was
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2
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6
Findings help clarify previous conflicting evidence regarding shingles risk post-vaccination.
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7
The study supports the benefits of COVID-19 vaccination amidst these small risks.
A recent study published in Drug Safety, led by Dr. Rana Jajou, shows a short-term increase in shingles risk within 28 days following an mRNA COVID-19 booster, based on data from over 2 million vaccinated individuals in the Netherlands. The self-controlled cohort design revealed a modest rise in herpes zoster consultations, particularly linked to the third booster dose of mRNA vaccines, such as Pfizer-BioNTech and Moderna. The authors emphasize the importance of interpreting this increased risk in light of the overall protective benefits of COVID-19 vaccination.
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