Tylenol in Pregnancy: New Review
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By
January 20, 2026
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3 min
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1
No significant link found between prenatal paracetamol and ASD/ADHD.
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2
Study used sibling-comparison design to account for confounders.
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3
Systematic review included 43 studies, evaluating risk factors.
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4
Meta-analysis supported current safety recommendations for paracetamol.
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5
Limitations include variability in exposure definitions and recall bias.
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6
Researchers emphasize continued use as recommended during pregnancy.
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7
Study lacked external funding or competing interests.
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A recent study has found no significant association between prenatal paracetamol exposure and the development of autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), or intellectual disability. This conclusion is based on pooled analyses from sibling-comparison designs, which mitigate shared genetic and environmental variables. While paracetamol is commonly advised during pregnancy, this systematic review evaluated the quality of 43 relevant studies, ensuring that adjusted risk estimates were reported. Findings support the continued recommendation of paracetamol's safety in pregnancy. Lead researchers Dr. Francesco D'Antonio and Dr. Maria Elena Flacco emphasize the consistency of their results, despite acknowledging limitations in exposure definitions and outcome classifications.
-
1
No significant link found between prenatal paracetamol and ASD/ADHD.
-
2
Study used sibling-comparison design to account for confounders.
-
3
Systematic review included 43 studies, evaluating risk factors.
-
4
Meta-analysis supported current safety recommendations for paracetamol.
-
5
Limitations include variability in exposure definitions and recall bias.
-
6
Researchers emphasize continued use as recommended during pregnancy.
-
7
Study lacked external funding or competing interests.
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