From the Journals

Could This Tool Reduce Antidepressant Dropout?

The PETRUSHKA platform uses clinical data and patient-reported side-effect priorities to rank antidepressant options and guide shared treatment decisions.

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  • 1

    PETRUSHKA tool personalizes antidepressant choices.

  • 2

    40% reduction in treatment discontinuation at 8 weeks.

  • 3

    540 patients participated across multiple sites.

  • 4

    Follow-ups at 4, 8, and 24 weeks post-randomization.

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    Patient preferences significantly inform treatment.

  • 6

    Open-label trial may affect result interpretation.

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    Majority of participants were White, limiting generalization.

  • 8

    No significant differences in depression or anxiety scores at 8 weeks.

Original Source(s)

Could This Tool Reduce Antidepressant Dropout?

The PETRUSHKA platform uses clinical data and patient-reported side-effect priorities to rank antidepressant options and guide shared treatment decisions.

  • by Kerri Miller

  • March 4, 2026

  • 5 min

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