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What I Learned Bringing Slalom Chromatography Back from the Dead

Fabrice Gritti spent a year immersed in the world of DNA physics to resurrect a long-abandoned technique to solve modern challenges in cell and gene therapy analysis

March 25, 2026
9 min

The Medicine Maker

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Slalom chromatography (SC) helps separate large DNA/RNA molecules.
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Initiated by Edward Bouvier's idea over a decade ago.
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The research team explored theoretical and experimental aspects of SC.
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Key findings about DNA migration and shear forces led to column development.
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Waters commercialized the first SC column, enhancing biopharmaceutical processes.
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Emphasis on interdisciplinary approach for scientific innovation.
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Importance of broad scientific education for researchers.

What I Learned Bringing Slalom Chromatography Back from the Dead

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What I Learned Bringing Slalom Chromatography Back from the Dead