Botulinum Toxin Evaluated in Digital Ischemia - Takeaway - MDSpire
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Botulinum Toxin Evaluated in Digital Ischemia

Individual-level meta-analysis examines response, dosing, and safety across ischemic etiologies

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    Botulinum toxin effectively treats digital ischemia, ulcers, and gangrene.

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    93% complete response for acute ischemia, 90% for ulcers.

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    Commonly used formulation: OnabotulinumtoxinA.

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    Minimal adverse events reported (e.g., 8% muscle weakness).

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    Predominantly female participants (75%), mean age

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    Underlying condition: systemic sclerosis (61%).

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    Treatment duration varied, fastest improvement in acute ischemia.

Original Source(s)

Botulinum Toxin Evaluated in Digital Ischemia

  • by Kathryn Wighton

  • April 3, 2026

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