Could Saliva Replace Blood for Cancer Screening?
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by Kerri Miller
August 6, 2025
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4 min
8 Key Takeaways
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1
New biosensor for breast cancer biomarkers HER2 & CA15-3 in saliva.
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2
Limit of detection is 1 femtogram/ml.
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3
Sensitivity is significantly better than ELISA methods.
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4
Enables real-time results for noninvasive screening.
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5
Study cohort included healthy participants and breast cancer patients.
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6
Combines results for high diagnostic accuracy.
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7
Potential for mobile health applications in rural areas.
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8
Further validation in larger populations needed.
A Bluetooth-enabled biosensor has been developed for rapid detection of breast cancer biomarkers HER2 and CA15-3 in saliva, achieving detection limits as low as one femtogram per milliliter, significantly outperforming conventional ELISA methods. This noninvasive technology facilitates immediate results, greatly beneficial for cancer screening, particularly in rural areas. The study led by Hsiao-Hsuan Wan from the University of Florida highlights the biosensor's high accuracy and sensitivity, supporting its potential for broader clinical use pending further validation.
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