From the Journals

Statin Side Effects Largely Unsupported by Trial Data

Most adverse effects listed on drug labels lack causal evidence, meta-analysis finds

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  • 1

    Most adverse effects of statins are unsupported by evidence.

  • 2

    Study involved 154,664 participants across 23 trials.

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    Only 4 of 66 additional outcomes showed significant excess risk.

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    Liver enzyme elevations related to more intensive statin regimens.

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    Adverse events derived from reports, possibly underestimating risks.

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    Public health implications due to misleading information on statins.

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    Call for revisions of statin labels for informed clinical decisions.

Original Source(s)

Statin Side Effects Largely Unsupported by Trial Data

Most adverse effects listed on drug labels lack causal evidence, meta-analysis finds

  • by Kerri Miller

  • February 17, 2026

  • 4 min

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