USO Tied to Lower HGSC Risk, Study Shows
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By
August 20, 2025
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3 min
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1
USO significantly reduces high-grade serous ovarian cancer risk by 36% compared to controls.
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2
The study included 42,306 women under 50 from Swedish registries.
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3
USO does not increase the risk of coronary artery disease or osteoporosis.
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4
Follow-up median time was 13 years, confirming consistency of results.
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5
Findings specific to premenopausal women under
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6
Limitations include unavailability of certain confounding factors.
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7
USO could serve as an alternative to BSO for cancer prevention.
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A retrospective cohort study published in PLOS Medicine indicates that women who underwent unilateral salpingo-oophorectomy (USO) have a 36% lower risk of developing high-grade serous ovarian cancer compared to matched controls. This research, led by Dr. Huan Yi, involved 42,306 women from Swedish registries between 1993 and 2018. Importantly, USO did not increase risks for coronary artery disease or osteoporosis, making it a favorable option for premenopausal women. The study suggests that USO is a viable alternative to bilateral salpingo-oophorectomy for cancer prevention without compromising bone and cardiovascular health.
-
1
USO significantly reduces high-grade serous ovarian cancer risk by 36% compared to controls.
-
2
The study included 42,306 women under 50 from Swedish registries.
-
3
USO does not increase the risk of coronary artery disease or osteoporosis.
-
4
Follow-up median time was 13 years, confirming consistency of results.
-
5
Findings specific to premenopausal women under
-
6
Limitations include unavailability of certain confounding factors.
-
7
USO could serve as an alternative to BSO for cancer prevention.
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