Clinical Guidelines
From the Journals

HPV Testing Guidelines Updated for Head and Neck Carcinomas

New evidence expands recommendations for sinonasal squamous cell carcinoma and standardizes p16 immunohistochemistry interpretation.

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  • 1

    Updated guidelines for HPV testing in head and neck carcinomas released by the College of American Pathologists

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    Recommendations include routine HPV testing in sinonasal squamous cell carcinoma

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    For oropharyngeal tissue specimens, p16 IHC is recommended as a surrogate marker

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    HPV-specific testing is emphasized for FNA specimens

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    DNA-ISH is not recommended for HPV-specific testing due to its lower sensitivity

Original Source(s)

HPV Testing Guidelines Updated for Head and Neck Carcinomas

New evidence expands recommendations for sinonasal squamous cell carcinoma and standardizes p16 immunohistochemistry interpretation.

  • by Kerri Miller

  • April 2, 2025

  • 4 min

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