Low DLCO/SB Linked to Faster SSc Progression - Takeaway - MDSpire
From the Journals

Low DLCO/SB Linked to Faster SSc Progression

Lower gas transfer at baseline was associated with higher unadjusted progression rates and shorter time to transition, though multivariable analysis did not identify independent predictors

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  • 1

    Lower DLCO/SB is linked to higher progression risk for SSc.

  • 2

    12% of studied patients progressed to definite SSc over 5 years.

  • 3

    The threshold DLCO/SB value for increased risk is below 70%.

  • 4

    SSc-specific antibodies contributed to progression risk.

  • 5

    Patients may experience lung function decline even without meeting disease classification criteria.

Original Source(s)

Low DLCO/SB Linked to Faster SSc Progression

  • by Andrea Surnit

  • April 6, 2026

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