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Shining a Light into the ADC Conjugation Black Box

A multi-year hunt for a “Goldilocks salt” paved the way for HIC-MS coupling and real-time ADC reaction monitoring

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  • 1

    Researchers have innovated HIC for real-time ADC monitoring.

  • 2

    Ammonium tartrate enhances HIC performance while enabling mass spectrometry.

  • 3

    Real-time analysis allows insights into bioconjugation reactions.

  • 4

    Reaction time reduced from 16 hours to 90 minutes.

  • 5

    Continuous stirring improves the reaction rate.

  • 6

    The study highlights the potential of advanced analytical techniques in pharmaceuticals.

  • 7

    A shift towards real-time process control in drug manufacturing is anticipated.

Original Source(s)

Shining a Light into the ADC Conjugation Black Box

A multi-year hunt for a “Goldilocks salt” paved the way for HIC-MS coupling and real-time ADC reaction monitoring

  • by James Strachan

  • March 5, 2026

  • 9 min

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