Researchers Kristofer Waldetoft and Sam Brown from Georgia Institute of Technology propose using alternative therapeutics for managing minor bacterial infections as a key strategy in combatting antibiotic resistance. They argue that the widespread prescription of antibiotics, even for mild conditions like pharyngotonsillitis, contributes to resistance across the microbiota, not just in the targeted pathogens. By utilizing antivirulence drugs or bacteriophages instead of traditional antibiotics, the selection pressure for resistance could be reduced, preserving antibiotic efficacy for severe infections.
1. Antibiotic resistance is worsened by treating mild infections with antibiotics. 2. Researchers suggest alternative therapies like antivirulence drugs. 3. Pharyngotonsillitis is a common mild infection contributing to resistance. 4. Systemic antibiotics influence the entire microbiota. 5. Bacteriophages can potentially reduce selection pressure on antibiotics. 6. New treatments for mild infections could preserve antibiotics for severe cases. 7. Alternative methods allow for targeted therapeutic approaches.
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